Management of extreme thrombocytosis in otherwise low-risk essential thrombocythemia; does number matter?
نویسندگان
چکیده
منابع مشابه
Antiplatelet therapy versus observation in low-risk essential thrombocythemia with a CALR mutation.
The role of antiplatelet therapy as primary prophylaxis of thrombosis in low-risk essential thrombocythemia has not been studied in randomized clinical trials. We assessed the benefit/risk of low-dose aspirin in 433 patients with low-risk essential thrombocythemia (271 with a CALR mutation, 162 with a JAK2(V617F) mutation) who were on antiplatelet therapy or observation only. After a follow up ...
متن کاملEssential thrombocythemia: a rare disease in childhood
Essential thrombocythemia is an acquired myeloproliferative disorder characterized by the proliferation of megakaryocytes in bone marrow, leading to a persistent increase in the number of circulating platelets and thus increasing the risk for thrombotic and hemorrhagic events. The disease features leukocytosis, splenomegaly, vascular occlusive events, hemorrhages and vasomotor disorders. The in...
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Thrombocytosis is a commonly encountered clinical scenario, with a large proportion of cases discovered incidentally. The differential diagnosis for thrombocytosis is broad and the diagnostic process can be challenging. Thrombocytosis can be spurious, attributed to a reactive process or due to clonal disorder. This distinction is important as it carries implications for evaluation, prognosis, a...
متن کاملManagement of essential thrombocythemia.
Essential thrombocythemia (ET) is a Philadelphia chromosome (Ph)-negative myeloproliferative neoplasm (MPN) characterized by thrombocytosis and megakaryocytic hyperplasia of the bone marrow, with presence of the JAK2 V617F mutation in 50%-60% of patients. ET evolves to myelofibrosis in a minority of cases, whereas transformation to acute leukemia is rare and increases in association with the us...
متن کاملCalreticulin and JAK2V617F Mutations in Essential Thrombocythemia and Their Potential Role in Diagnosis and Prognosis
ET was first recognized in 1934 by the name of hemorrhagic thrombocythemia. ET is characterized by an unusual thrombocytosis and risk of thrombotic and hemorrhagic disorders. The annual incidence of ET is approximately 1-2.5 per 100,000 population [1]. The incidence of ET is higher in those 50-70 years old, and is most often incidentally detected during a high platelet count. A number of patien...
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عنوان ژورنال:
- Blood
دوره 108 7 شماره
صفحات -
تاریخ انتشار 2006